Abstract
Citation: IFSCC Magazine, 11 (2008) (2) 105–112Abstract: A novel photoprotective ingredient with anti‐oxidant and electrophilic scavenging properties was designed. A structure–activity relationship study was conducted in order to optimize its bioavailability, specifically its ability to reach deep layers of the skin that may be affected by ultraviolet radiation‐induced oxidative stress. A particular characteristic of this compound is its ability to release taurine upon reaction with some reactive oxygen species. In situ taurine formation may contribute to photoprotection. Preliminary in vitro experiments provide some evidence for effective protection against UVA‐induced oxidative stress. Scavenging of the electrophilic species 4‐hydroxynonenal, a highly cytotoxic end product of membrane lipid peroxidation, seems to be 2‐oxo‐1,3‐thiazolidine major photoprotective mechanism.Keywords: antioxidant, electrophilic species scavenging, photoprotection, structure‐activity relationship, taurinePaper presented at the IFSCC Conference 2007, Amsterdam, The Netherlands
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