DESIGN ALGINATE BASED BLENDS FOR LIVING COMPOSITE FIBERS TO PROMOTE WOUND HEALING

Abstract

The currently used approaches in the treatment of wounds and burns have been studied for many years to eliminate problems related with mechanical strength, elasticity, biocompatibility and cost. Nowadays, fabrication of composite fibers by a fiber as core and hydrogels as shell, which can be seeded by cells is rapidly increasing. In this study, it is aimed to produce a natural polymer-based dressing that can provide controlled antibiotic release to accelerate wound healing with low cost and high efficiency. The composites have been achieved by using surgical suture as a core and alginate in the shell part, which modified with starch and gelatin. Evaluating low-cost hydrogel material such as alginate, starch and gelatin in the shell layer of composite fibers by different concentrations were investigated in addition to study their swelling and drug release behaviors. The parameters for the model of an antibiotic release that can prevent common infections can be manipulated by using a biotextile-based approach to quantify the amount of antibiotics and its release to satisfy clinical requirements. Toluidine blue and Penicillin/Streptomycin were chosen as antibiotic models for drug release experiments. Moreover, human adipose tissue-derived mesenchymal stem cells (hAT-MSCs) were applied to evaluate cell viability experiments. Results demonstrated that alginate modified starch and gelatin can be used as low-cost and promising materials for use in biomedical applications.