Abstract
revealed amucocutaneousKaposi sarcoma. TheKS lesion cells showed a high positivity of CD31, CD34, and HHV-8 immunoreactivities. Viral serology (HIV, hepatitis B and C virus, Epstein–Barr virus and cytomegalovirus) was negative. The diagnosis of HHV8 infection responsible for HLS as well as for KS was retained. Comments: HLS is a severe life-threatening disorder which can be associated to malignancies, to autoimmunes disorders and to infections. Herpes viruses are the most frequent microbial cause of HLS in more than half of the cases. On the other hand, HHV8 is the principal pathogenesis factor of KS, since over 95% of KS lesions, regardless of their clinical type, have been found to be infected with HHV-8. According to our review of the previous literatures there are few cases of HLS associated with a KS.
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