Dermatologic Manifestations and Pulmonary Involvement in Two Patients with Hypereosinophilic Syndrome - A Case Series

Abstract

Hypereosinophilic syndrome is a group of disorders described by excessive production of eosinophils, their infiltration and the release of mediators that cause damage to multiple organs. Two patients of 67 and 38 years old, were referred to the clinic of Hematology and Oncology, Kermanshah, Iran, in 2016 and 2017, respectively. In the first case, there was no suspicious item in the patient's medical records and his most prominent features were pulmonary emphysema, and hypopigmented lesions, while in the second case, in addition to having a history of asthma, lesions of eczema were also seen. Hence, according to these characteristics and the results of the tests performed, our differential diagnosis was the Hypereosinophilic syndrome. We started the treatment with two types of drugs, Imatinib and Prednisolone. The treatment of patients is still ongoing and their condition was relatively promising.