Abstract
In this study, a thorough investigation of parylene coatings was conducted, as follows: microstructure (i.e., X-ray diffractometer (XRD) and cold field emission scanning electron microscope (FESEM)), mechanical property (i.e., pencil hardness and cross-cut adhesion test), surface property (i.e., water contact angle measurement, IR, and X-ray photoelectron spectroscopy (XPS)), and biocompatibility tests (i.e., fibroblast cell culture, platelet adhesion, and animal studies). The results revealed that parylene, a crystalline and brittle coating, exhibited satisfactory film adhesion and relative hydrophobicity, thereby contributing to its effective barrier properties. Fibroblast cell culturing on the parylene-deposited specimen demonstrated improved cell proliferation and equivalent to or superior blood compatibility than that of the medical-grade silicone (currently used clinically). In the animal study, parylene coatings exhibited similar subcutaneous inflammatory reactions compared with the medical-grade silicone. Both in vitro and in vivo tests demonstrated the satisfactory biocompatibility of parylene coatings.
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