Abstract
Regenerative medicine literature has proposed mesenchymal stem/progenitor cell- (MSC-) mediated therapeutic approaches for their great potential in managing various diseases and tissue defects. Dental MSCs represent promising alternatives to nondental MSCs, owing to their ease of harvesting with minimally invasive procedures. Their mechanism of action has been attributed to their cell-to-cell contacts as well as to the paracrine effect of their secreted factors, namely, secretome. In this context, dental MSC-derived secretome/conditioned medium could represent a unique cell-free regenerative and therapeutic approach, with fascinating advantages over parent cells. This article reviews the application of different populations of dental MSC secretome/conditioned medium in in vitro and in vivo animal models, highlights their significant implementation in treating different tissue' diseases, and clarifies the significant bioactive molecules involved in their regenerative potential. The analysis of these recent studies clearly indicate that dental MSCs' secretome/conditioned medium could be effective in treating neural injuries, for dental tissue regeneration, in repairing bone defects, and in managing cardiovascular diseases, diabetes mellitus, hepatic regeneration, and skin injuries, through regulating anti-inflammatory, antiapoptotic, angiogenic, osteogenic, and neurogenic mediators.
Highlights
Regenerative medicine employing tissue engineering approaches represents a promising emerging multidisciplinary branch of medicine that is aimed at regenerating as well as guiding restoration and enhancement of organs and tissues’ functions, thereby improving the overall quality of life [1]
We aim to investigate the efficacy of secretome derived from various dental mesenchymal stem/progenitor cell populations in the therapeutic approaches of various diseases as well as on different tissues’ regeneration, highlighting the bioactive molecules involved in their action
Dental mesenchymal stem/progenitor cell- (MSC-)derived secretome holds a multitude of capacities for tissue engineering and regenerative medicine
Summary
Regenerative medicine employing tissue engineering approaches represents a promising emerging multidisciplinary branch of medicine that is aimed at regenerating as well as guiding restoration and enhancement of organs and tissues’ functions, thereby improving the overall quality of life [1]. The expression of these osteogenic proteins could open numerous possibilities for applications of dental MSC-CM in the regeneration of bone disorders
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
