Abstract
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a serious complication of therapy with antiresorptive drugs, such as bisphosphonates (BFs). Although it occurs more often in oncology patients who use intravenous BFs, patients who use oral BFs for osteoporosis are also in the risk group, especially when surgical dental procedures such as dental extraction or dental implants are performed. We report 3 cases of patients who received BF therapy in the past or were still using the medication during dental implant surgery and developed BRONJ and loss of the implants. Prior knowledge by dentists of the adverse effects of BF therapy in patients requiring dental rehabilitation is extremely important in the management of these patients, since BFs may impair the longevity of the dental implant as well as induce osteonecrosis of the jaws, compromising not only oral health but also negatively interfering in the quality of life of these patients. Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a serious complication of therapy with antiresorptive drugs, such as bisphosphonates (BFs). Although it occurs more often in oncology patients who use intravenous BFs, patients who use oral BFs for osteoporosis are also in the risk group, especially when surgical dental procedures such as dental extraction or dental implants are performed. We report 3 cases of patients who received BF therapy in the past or were still using the medication during dental implant surgery and developed BRONJ and loss of the implants. Prior knowledge by dentists of the adverse effects of BF therapy in patients requiring dental rehabilitation is extremely important in the management of these patients, since BFs may impair the longevity of the dental implant as well as induce osteonecrosis of the jaws, compromising not only oral health but also negatively interfering in the quality of life of these patients.
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