Abstract
The human teeth and oral cavity harbor various populations of mesenchymal stem cells (MSCs), so called dental-derived stem cells (D-dSCs) with self-renewing and multilineage differentiation capabilities. D-dSCs properties involves a strong paracrine component resulting from the high levels of bioactive molecules they secrete in response to the local microenvironment. Altogether, this viewpoint develops a general picture of current innovative strategies to employ D-dSCs combined with biomaterials and bioactive factors for regenerative medicine purposes, and offers information regarding the available scientific data and possible applications.
Highlights
Mesenchymal stem cells (MSCs) may play a main role in regenerative medicine, and some clinical studies have demonstrated that MSCs from different sources may have the ability to repair injured tissues, such as bone (Salgado et al, 2020; Gugliandolo et al, 2021) and corneal tissue engineering (Nosrati et al, 2021a), wound healing and muscle (Martínez-Sarrà et al, 2017), cartilage regeneration (Mata et al, 2017; Dang et al, 2021), as well spinal cord injuries (Asadi-Golshan et al, 2021)
The present viewpoint develops a general overview of current innovative strategies to (I) employ DdSCs combined with biological waste biomaterials, from renewable and biodegradable bioactive compounds, to obtain new materials having lower cost and comparable properties, for bone regenerative medicine purposes, and (II) offers information regarding the available scientific data and possible applications of derived stem cells (D-dSCs) use
CD39 and CD73 are coexpressed on gingival mesenchymal stem cells (GMSCs) and regulate T cells, which play a catalytic Huang et al (2017) role to promote immune regulation and reduce inflammation
Summary
Dental-derived stem cells and biowaste biomaterials: What’s in bone regenerative medicine applications.
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