Abstract
The aim of this study was to evaluate the effects of the autogenous demineralized dentin matrix (ADDM) on the third molar socket wound healing process in humans, using the guided bone regeneration technique and a polytetrafluoroethylene barrier (PTFE). Twenty-seven dental sockets were divided into three groups: dental socket (Control), dental socket with PTFE barrier (PTFE), and dental socket with ADDM slices associated to PTFE barrier (ADDM + PTFE). The dental sockets were submitted to radiographic bone densitometry analysis and statistical analysis on the 15th, 30th, 60th and 90th days using analysis of variance (ANOVA) and Tukey's test (p < or = 0.05). The radiographic analysis of the ADDM + PTFE group showed greater homogeneity of bone radiopacity than the Control group and the PTFE group, during all the observation times. The dentin matrix gradually disappeared from the dental socket during the course of the repair process, suggesting its resorption during the bone remodeling process. It was concluded that the radiographic bone density of the dental sockets treated with ADDM was similar to that of the surrounding normal bone on the 90th day. The ADDM was biocompatible with the bone tissue of the surgical wounds of human dental sockets. The radiographic analysis revealed that the repair process was discreetly faster in the ADDM + PTFE group than in the Control and PTFE groups, although the difference was not statistically significant. In addition, the radiographic image of the ADDM + PTFE group suggested that its bone architecture was better than that of the Control and PFTE groups.
Highlights
The repair of bone defects resulting from trauma, infections, neoplasias or developmental abnormalities represents a challenge for maxillomandibular complex surgeries.[4]
The present study evaluated radiographic bone density and the effects of autogenous demineralized dentin matrix slices (ADDM) on the third molar socket wound healing process in humans, using the guided bone regeneration technique with polytetrafluoroethylene barrier (PTFE) barrier
The 27 dental sockets of lower third molars were divided into three groups: Control group, PTFE group, and ADDM + PTFE
Summary
The repair of bone defects resulting from trauma, infections, neoplasias or developmental abnormalities represents a challenge for maxillomandibular complex surgeries.[4]. Its objective is to guide sufficient bone neoformation in order to close any bone defect in maxillomandibular processes This phenomenon is probably controlled by complex molecular interactions, cellular messages of short or long extension, affecting the speed and duration of the osteoblastic and osteoclastic activity, as well as proliferation, differentiation, and chemotaxis of special cells.[3,7,9,13] Some authors have stated that cellular proliferation begins with local stimulating factors, that are bone morphogenetic proteins (BMP).[1,3,9] In addition to BMP, ADDM slices are rich in other growth factors such as transforming growth factor-beta (TGF-beta), fibroblast growth factor (FGF), platelet-derived growth factor (PDGF) and epidermal growth factor (EGF).[2,6,8]
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