Abstract
The densities of dopamine D 2 recognition sites labelled with [ 3H]sulpiride were determined in the caudate-putamen, nucleus accumbens (medial and lateral portions), olfactory tubercle, substantia nigra (pars reticulata and pars compacta), and ventral tegmental area (VTA) of alcohol-naive, selectively bred P ( N = 7) and NP ( N = 7) rats using quantitative autoradiography. The binding of [ 3H]sulpiride was 20–25% lower ( P < 0.05) in the caudate-putamen, medial and lateral nucleus accumbens, and VTA of the P compared with the NP rats. No significant differences were observed between the P and NP rats in the olfactory tubercle or substantia nigra. [ 3H]Sulpiride binding, using standard membrane preparations, established with Scatchard analysis that the difference in the densities of D 2 recognition sites in the caudate-putamen between the P and NP rats was due to lower B max values for the P line. The results indicate that the number of dopamine D 2 receptor sites is lower in several central nervous system regions of the P rats compared to NP rats.
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