Abstract
Dendritic cells (DCs) and natural killer (NK) cells shape each other’s functions early during immune responses. DCs activate NK cells and NK cells can mature or kill DCs. In this review we will discuss which DC and NK cell subsets are mainly affected by this interaction, where these encounters might take place and which signals are exchanged. Finally, we will point out what the clinical benefit of understanding this interaction might be and how it changed our view on NK cells as innate lymphocytes.
Highlights
Natural killer (NK) cells have originally been described by their function to spontaneously lyse tumor and infected cells [1,2,3]
Human cDCs can be subdivided in two additional subsets, CD1c+ (BDCA1+) and CD141+ (BDCA3+) dendritic cells (DCs), which have been found in the skin, liver, and lung, in addition to primary and secondary lymphoid tissues [14]
In recent years it has become apparent that DCs can in addition to being superior antigen presenting cells for T cell priming, activate innate lymphocytes [69]
Summary
Viral Immunobiology, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland. Edited by: Carsten Watzl, Leibniz Research Centre for Working Environment and Human Factors – IfADo, Germany. National Jewish Health, USA Evelyn Ullrich, Goethe University Frankfurt, Germany. Dendritic cells (DCs) and natural killer (NK) cells shape each other’s functions early during immune responses. DCs activate NK cells and NK cells can mature or kill DCs. In this review we will discuss which DC and NK cell subsets are mainly affected by this interaction, where these encounters might take place and which signals are exchanged. We will point out what the clinical benefit of understanding this interaction might be and how it changed our view on NK cells as innate lymphocytes
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