Abstract
The penetration of triamcinolone acetonide (TACA) through human epidermis following the evaporation of a finite dose of a hydroalcoholic tincture correlates positively with the applied volume and the penetrated amount of ethanol. The incorporation of salicylic acid into such a tincture extends the lag time and linear region of the TACA penetration curve. Covering with Actiderm following evaporation of a hydroalcoholic vehicle increases 2–3-fold the TACA flux with respect to uncovered skin or to occlusion with Saran Wrap. Solubility and partition coefficient determinations indicate similar thermodynamic activities for the drug in the three tinctures tested; however, diffusion experiments under in vivo mimic conditions show a higher TACA flux for the vehicle composed of isopropyl palmitate and ethanol. This phenomenon probably arises from different kinetics of the diffusion process in circumstances mimicking the in vivo conditions where vehicle components evaporate.
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