Abstract
We previously showed that neonatal injection of allogeneic fetal liver cells (FLC) or semi-allogeneic spleen cells (F1SC) induced long-term acceptance of both donor-type and third-party cardiac grafts, however the mechanism remains unclear. In this study, we used as recipients 2C transgenic mice expressing a T cell receptor (TCR) specific for Ld class I MHC antigen to monitor the effects of neonatal treatment with FLC or F1SC.
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