Abstract
The aim of this study was to develop a delayed-release matrix pellet containing atenolol as active pharmaceutical ingredient. The matrix additionally contained trisodium phosphate dodecahydrate as alkalizing pore-former agent to enhance the dissolution of the atenolol at pH 6.8. The delayed release was ensured by coating with a gastro-resistant polymer. For this purpose, an acryl EZE MP aqueous dispersion was used, which is suggested in the literature for pellet coating. Before this functional film coating, a protective polymer layer was developed, to prevent direct contact between the alkalizing layer and the acryl EZE. The results of in vitro dissolution tests demonstrated that the double-coated pellet preparation is a delayed-release solid dosage form.
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