Abstract
A single intragastric (i.g.) feeding of 20 mg of ovalbumin (OVA) or human gammaglobulin (HGG) to normal adult BDF1 mice produces specific tolerance to later parenteral immunization with the antigen. Previous work showed that the tolerance induced by feeding could subsequently be abolished by lethal whole-body irradiation. OVA-specific antibody responses were indistinguishable in normal and orally-tolerized mice that were irradiated and then injected with normal spleen cells immediately prior to immunization (1). In the present study, we examined the effects of irradiation and “reconstitution” with normal spleen cells on the induction of tolerance by OVA and HGG feeding.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
