Abstract
Background and Aims: The co-stimulatory CD40-CD40L axis is a major driver of atherosclerosis. T-cell CD40L and dendritic cell (DC) CD40 expression are required for optimal T-cell expansion, but their cell-specific role in atherosclerosis remains elusive. We hypothesize that T-cell CD40L and DC CD40 signaling plays a significant role in atherosclerosis.
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