Abstract
ADH exerts its effect on urinary volume and concentration via intra-cellular cyclic AMP generation. The integrity of this system can be studied by measuring urinary cAMP excretion following ADH administration. This was carried out by infusing ADH (0.5 to 1.0 mU/min) to 4 NDI girls in a state of water diuresis. These NDI girls presented during a 10 year period to a large children's hospital. For comparison, the same procedure was carried out in 2 normal adults, who showed 100% Increase in UcAMP, and in 3 NDI boys who showed no increase in UcAMP. The absence of any effect of ADH on UcAMP in girls differs from the result obtained in one previous case reported and demonstrates that females with this disorder are also afflicted with a deficient ADH-sensitive adenyl cyclase system.
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