Deep Inspiration Breath Hold [18F]FDG PET-CT on 4-rings scanners in evaluating lung lesions: Evidences from a phantom and a clinical study

Deep Inspiration Breath Hold [18F]FDG PET-CT on 4-rings scanners in evaluating lung lesions: Evidences from a phantom and a clinical study

Background: Adjuvant regional nodal irradiation (RNI) after breast conserving surgery or mastectomy is supported by clinical trials for patients with node-positive breast cancer. RNI results in increased radiation dose to organs-at-risk (OARs) such as the heart and lungs. While regular acquisition of both free breathing (FB) and deep inspiration breath hold (DIBH) scans has been widely adopted for left-sided breast cancers (LBCs) as a cardiac-sparing technique, DIBH scans are not routinely acquired for right-sided breast cancers (RBCs). Therefore, when OAR constraints cannot be met with 3D conformal radiation therapy (3DCRT) planning on the FB scan, the only option is intensity modulated radiation therapy (IMRT), with its inherent increased cost, resource utilization, and requirement for insurance authorization. Given these challenges, we have regularly acquired FB and DIBH scans for right-sided RNI since 2018. We hypothesized that acquisition of DIBH scans would result in a reduced need for IMRT and reduced dose to OARs. Methods: We retrospectively identified patients who were treated with right-sided RNI who had both FB and DIBH scans. All patients had target volumes (breast or chest wall and regional lymph nodes [undissected axillary, supraclavicular, and internal mammary nodes]) prospectively contoured on the FBCT scan based upon the RTOG Breast Atlas. This initiated a treatment planning algorithm that began with creating a FB 3DCRT plan and changed to DIBH 3DCRT then FB IMRT when OAR constraints could not be met while maintaining acceptable planning target volume (PTV) coverage. For patients who did not have contours available on the DIBH scan, the treating physician retrospectively completed the PTV contours. For each patient, three total plans were created for comparison using our institutional target coverage and OAR metrics: FB 3DCRT, FB IMRT, and DIBH 3DCRT. We compared PTV coverage and doses to multiple OARs including the contralateral breast, esophagus, heart, lungs (left, right, total lung dose), and liver. PTV coverage and OAR doses were evaluated by a one-way ANOVA followed by Bonferroni comparison. A p < 0.05 was considered statistically significant.Results: We identified 38 patients in whom FB and DIBH scans were acquired. Only 32% (N=12) were treated with the standard FB 3DCRT. Of the remaining 26 patients 73% (N=19) were treated DIBH 3DCRT, and only 27% (N=7) were treated with FB IMRT, resulting in a FB IMRT rate of 18% overall. Without DIBH scans, 68% (N=19) would have advanced to FB IMRT. Dosimetric comparison across these 38 patients (N=114 plans) demonstrated that DIBH 3DCRT had at least equivalent OAR metrics as compared to FB 3DCRT, with significant improvement in max heart dose (9.6 Gy vs. 14.9 Gy; p = 0.034), right lung V20 (32.1% vs 37.8%; p < 0.01), mean total lung dose (8.9 Gy vs. 10.5 Gy; p < 0.01), and mean liver dose (1.8 Gy vs. 4.0 Gy; p < 0.01). FB IMRT plans resulting in significantly lower right lung V20 (26.3% FB IMRT vs. 37.8% FB 3DCRT vs. 32.1% DIBH 3DCRT), but resulted in higher dose to the heart and contralateral breast: mean heart dose (2.2 Gy FB IMRT vs. 1.0 Gy FB 3DCRT vs. 0.9 Gy DIBH 3DCRT; p < 0.01), maximum heart dose (16.4 Gy FB IMRT vs. 14.9 Gy FB 3DCRT vs. 9.6 Gy DIBH 3DCRT; p < 0.01) and contralateral breast D5% (5.0 Gy FB IMRT vs. 2.9 Gy FB 3DCRT vs. 3.0 Gy DIBH 3DCRT; p < 0.01).Conclusions: We found that acquiring DIBH scans for RBC patients receiving RNI reduced the need for FB IMRT from 68% to 18%. As compared to FB 3DCRT, DIBH 3DCRT resulted in in equivalent target coverage with significantly lower lung and liver doses. FB IMRT is useful to keep the right lung V20 within acceptable limits at the expense of higher dose to other OARs. Our data support the routine acquisition of DIBH scans in RBC patients undergoing RNI in order to decrease the proportion of patients that require FB IMRT. Citation Format: Sachin R Jhawar, Kylee Lindsey, Karla Kuhn, Kayla Tedrick, Ian Zoller, William Taylor, Eric Cochran, Erin Healy, Sasha Beyer, Julia White, Jose G Bazan. Should deep inspiration breath hold scans be standardly acquired for right-sided breast/chestwall and regional nodal irradiation? [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P3-19-02.

Purpose:Deep inspiration breath hold (DIBH) for left‐sided breast cancer has been shown to reduce heart dose. Surface imaging helps to ensure accurate breast positioning, but does not guarantee a reproducible breath hold (BH) at DIBH treatments. We examine the effects of variable BH positions for DIBH treatments.Methods:Twenty‐Five patients with free breathing (FB) and DIBH scans were reviewed. Four plans were created for each patient: 1) FB, 2) DIBH, 3) FB_DIBH – the DIBH plans were copied to the FB images and recalculated (image registration was based on breast tissue), and 4) P_DIBH – a partial BH with the heart shifted midway between the FB and DIBH positions. The FB_DIBH plans give “worst case” scenarios for surface imaging DIBH, where the breast is aligned by surface imaging but the patient is not holding their breath. Students t‐tests were used to compare dose metrics.Results:The DIBH plans gave lower heart dose and comparable breast coverage versus FB in all cases. The FB_DIBH plans showed no significant difference versus FB plans for breast coverage, mean heart dose, or maximum heart dose (p >= 0.10). The mean heart dose differed between FB_DIBH and FB by < 2 Gy for all cases, the maximum heart dose differed by < 2 Gy for 21 cases. The P_DIBH plans showed significantly lower mean heart dose than FB (p = 0.01). The mean heart doses for the P_DIBH plans were < FB for 22 cases, the maximum dose < FB for 18 cases.Conclusions:A DIBH plan delivered to a FB patient set‐up with surface imaging will yield similar dosimetry to a plan created and delivered FB. A DIBH plan delivered with even a partial BH can give reduced heart dose compared to FB techniques when the breast tissue is well aligned.

Prospective Assessment of Deep Inspiration Breath Hold Using 3-Dimensional Surface Tracking for Irradiation of Left-Sided Breast Cancer

How Important Is a Reproducible Breath Hold for Deep Inspiration Breath Hold Breast Radiation Therapy?

126 Background: DIBH during radiation of left breast cancers reduces heart dose, potentially reducing late cardiac ischemic events, but requires a treatment CW position significantly different from a free-breathing (FB) position. We sought to improve the accuracy of radiation therapy during DIBH by using electromagnetic surface transponders to track the position of the CW during treatment. We examined the benefit of this technique in reducing dose to the heart and consistently reproducing the DIBH position. We also evaluated the difference between FB and DIBH CW position and compared CW movement within the plateau of each DIBH to within beam-on time. Methods: 15 patients participated in this IRB-approved study. Patients were planned and treated using DIBH. We fused treatment-position FB CT scans to DIBH scans to compare mean heart (MH) and left anterior descending coronary artery (LAD) dose. We used surface transponder tracking reports to determine CW motion at the time of daily port films, during FB, the plateau of each DIBH, and beam-on time. We summed anterior and superior motion using the Pythagorean Theorem and report our results in this combined axis. Paired t-test was used to compare heart dose with vs. without DIBH and CW motion during plateau DIBH vs. beam-on. Results: DIBH significantly reduced MH and LAD dose vs. FB plans (MH 1.26 ± 0.51 Gy v 2.84 ± 1.55 Gy, p < 0.01), (LAD 5.49 ± 4.02 Gy v 18.15 ± 8.78 Gy, p < 0.01). DIBH CW position was a mean of 13.9 ± 5.3 mm anterior and superior to FB position. The mean difference in CW position at the time of daily port film vs. beam-on was -1.0 ± 2.5 mm. Plateau DIBH CW motion was 2.8 ± 2.3 mm, significantly increased from CW motion during beam-on (1.1 ± 1.2 mm, p < 0.01). Treatment was paused in 23% of fractions to adjust for suboptimal breath hold or CW position. Conclusions: DIBH reduced the MH and LAD dose by at least 50%. Real-time tracking with electromagnetic transponders allowed us to limit treatment to the most stable portion of the DIBH plateau, significantly reducing intra-fraction motion. Electromagnetic confirmation of CW position allowed verification of breath-hold reproducibility.

Purpose: To investigate the cardio-pulmonary doses between Deep Inspiration Breath Hold (DIBH) and Free Breathing (FB) technique in left sided breast irradiation. Materials & Methods: DIBH CT and FB CT were acquired for 10 left sided breast patients who underwent whole breast irradiation with or without nodal irradiation. Three fields single isocenter technique were used for patients with node positive patients along with two tangential conformal fields whereas only two tangential fields were used in node negative patients. All the critical structures like lungs, heart, esophagus, thyroid, etc., were delineated in both DIBH and FB scan. Both DIBH and FB scans were fused with the Dicom origin as they were acquired with the same Dicom coordinates. Plans were created in the DIBH scan for a dose range between 50 Gy in 25 fractions. Critical structures doses were recorded from the Dose Volume Histogram for both the DIBH and FB data set for evaluation. Results: The average mean heart dose in DIBH vs FB was 13.18 Gy vs 6.97 Gy, (p = 0.0063) significantly with DIBH as compared to FB technique. The relative reduction in average mean heart dose was 47.12%. The relative V5 reduced by 14.70% (i.e. 34.42% vs 19.72%, p = 0.0080), V10 reduced by 13.83% (i.e. 27.79 % vs 13.96%, p = 0.0073). V20 reduced by 13.19% (i.e. 24.54 % vs 11.35%, p = 0.0069), V30 reduced by 12.38% (i.e. 22.27 % vs 9.89 %, p = 0.0073) significantly with DIBH as compared to FB. The average mean left lung dose reduced marginally by 1.43 Gy (13.73 Gy vs 12.30 Gy, p = 0.4599) but insignificantly with DIBH as compared to FB. Other left lung parameters (V5, V10, V20 and V30) shows marginal decreases in DIBH plans compare to FB plans. Conclusion: DIBH shows a substantial reduction of cardiac doses but slight and insignificant reduction of pulmonary doses as compared with FB technique. Using the simple DIBH technique, we can effectively reduce the cardiac morbidity and at the same time radiation induced lung pneumonitis is unlikely to increase.

Postoperative radiation therapy (RT) is the standard treatment for almost all patients diagnosed with breast cancer. Even with modern RT techniques, parts of the heart may still receive higher doses than those recommended by clinically validated dose limit restrictions, especially when the left breast is irradiated. Deep inspiration breath hold (DIBH) may reduce irradiated cardiac volume compared to free breathing (FB) treatment. This study aimed to evaluate the dosimetric impact on the heart and left anterior descending coronary artery (LAD) in FB and DIBH RT planning in patients with left breast cancer. A retrospective cohort study of women diagnosed with left-sided breast cancer submitted to breast surgery followed by postoperative RT from 2015 to 2019. All patients were planned with FB and DIBH and hypofractionated dose prescription (40.05 Gy in 15 fractions). 68 patients were included in the study. For the coverage of the planned target volume evaluation [planning target volume (PTV) eval] there was no significant difference between the DIBH versus FB planning. For the heart and LAD parameters, all constraints evaluated favored DIBH planning, with statistical significance. Regarding the heart, median V16.8 Gy was 2.56% in FB vs. 0% in DIBH (p < 0.001); median V8.8 Gy was 3.47% in FB vs. 0% in DIBH (p < 0.001) and the median of mean heart dose was 1.97 Gy in FB vs. 0.92 Gy in DIBH (p < 0.001). For the LAD constraints D2% < 42 Gy, the median dose was 34.87 Gy in FB versus 5.8 Gy in DIBH (p < 0.001); V16.8 Gy < 10%, the median was 15.87% in FB versus 0% in DIBH (p < 0.001) and the median of mean LAD dose was 8.13Gy in FB versus 2.92Gy in DIBH (p < 0.001). The DIBH technique has consistently demonstrated a significant dose reduction in the heart and LAD in all evaluated constraints, while keeping the same dose coverage in the PTV eval.

This study aims to evaluate the reduction of cardiac radiation dose and volume with deep inspiration breath hold (DIBH) technique compared to free breathing (FB) in patients with left-sided breast cancer. The study also aims to evaluate whether the benefits of DIBH vary in patients who had whole breast radiotherapy (RT) after breast-conserving surgery (BCS) and those who had chest wall RT post-mastectomy (M). FB and DIBH plans were generated for 15 consecutive post-BCS patients and 17 post-M patients who underwent RT with DIBH using varian real-time position management (RPM) system. Cardiac shields were used in all post-BCS plans, provided that clinical treatment volume coverage was not compromised, while chest wall coverage took priority in post-M plans. The prescribed dose was 50Gy in 25 fractions for the whole breast or the chest wall. Parameters of interest were cardiac V5, mean LAD dose, maximum LAD dose, and mean heart dose. The impact of DIBH was compared in post-BCS and post-M patients using paired t tests. To gauge clinically meaningful outcome, the proportion of patients with V5<5% and mean cardiac dose <2Gy were compared using McNemar's test. DIBH decreased V5 by an absolute 4.5% (2.3 vs. 6.8%; p<0.0001) in post-M group, and by an absolute 2.4% (1.3 vs. 3.7%; p=0.0028) in post-BCS group. DIBH decreased the mean heart dose by 107.0cGy (127.4 vs. 234.4cGy; p=0.0002) in post-M group, and by 58.9cGy (82.2 vs. 141.1cGy; p=0.0012) in post-BCS group. DIBH decreased mean LAD by 1201.6cGy (670 vs. 1872.5cGy; p=0.0006) in post-M group, and by 799.0cGy (425.3 vs. 1224.3cGy; p=0.0003) in post-BCS group. DIBH also decreased max LAD dose by 1244.3cGy (2776.0 vs. 4020.3cGy; p=0.0014) in post-M group, and by 1856.3cGy (1898.7 vs. 3754.9cGy; p=0.0005) in post-BCS group. In post-BCS group, cardiac V5<5% was achieved in 10/15 (67%) FB patients, and in 15/15 (100%) DIBH patients (p=0.002), and mean heart dose <2Gy was achieved in 12/15 (80%) FB patients and in 15/15 (100%) DIBH patients (p<0.001). This compares with post-M group, in which V5<5% was achieved in 6/17 (35%) FB patients and in 16/17 (94%) DIBH patients (p=0.05), and mean heart dose <2Gy was achieved in 7/17 FB (41%) an 16/17 DIBH patients (94%) (p=0.03). The results of this study suggest that there is considerable reduction in cardiac exposure in most patients with DIBH compared to FB, although less reduction is observed in the post-BCS patients. The use of cardiac shields and collimators/gantry adjustments, more readily applicable for post-BCS cases, may limit the additional benefits of DIBH. In an environment where DIBH availability is limited, the result of this study supports the preferential use of DIBH in post-M patients over post-BCS patients.

Cardiac dose reduction using deep inspiratory breath hold (DIBH) in radiation treatment of left sided breast cancer patients with breast conservation surgery and modified radical mastectomy

Purpose To compare the accuracy of a single 20-second deep-inspiration breath hold (DIBH) in fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) to that with conventional free-breathing (FB) whole-body PET/CT for the assessment, characterization, and quantification of lung lesions in terms of the blurring effect of respiratory motion. Materials and Methods Institutional review board approval was obtained, and the requirement to obtain informed consent was waived. A preclinical study was performed in a test population of 19 patients to evaluate the feasibility and consistency of DIBH techniques compared with phase-based respiratory gating (PBRG). One hundred fifteen patients with lung lesions were then prospectively included and assessed with FB PET/CT followed by 20-second DIBH PET/CT. Maximum standardized uptake value (SUVmax), peak standardized uptake value (SUVpeak), and number and size of nodules were reported for each acquisition and then compared with findings from histopathologic examination and/or clinical-radiologic follow-up. Statistical analysis was performed with the t test, χ2 test, Pearson correlation coefficient, and receiver operating characteristic analysis. Results In the test population, data obtained with DIBH PET and PBRG PET showed close correlation (r = 0.94, P < .001 for SUVmax and r = 0.98, P < .001 for SUVpeak). In the clinical population, both SUVmax and SUVpeak were significantly increased with DIBH compared with FB (5.60 ± 4.20 vs 3.11 ± 1.80 and 2.25 ± 1.75 vs 1.71 ± 0.96, respectively; P < .001). A significantly greater number of lung lesions was detected with DIBH PET/CT compared with FB PET/CT (P < .001), with the detection of 70 additional nodules and more accurate coregistration of 84. According to the area under the receiver operating characteristic curve for SUVpeak, DIBH demonstrated a higher level of accuracy than did FB (P = .039). Conclusion The DIBH PET/CT technique is feasible in routine clinical practice and is more sensitive for quantitative measurements and lesion localization. This technique reduces the blurring effect of respiratory motion, thus improving the diagnostic accuracy for lung nodules. © RSNA, 2017.

BackgroundDeep inspiration breath hold (DIBH) reduces heart and left anterior descending artery (LAD) dose during left-sided breast radiation therapy (RT); however there is limited information about which patients derive the most benefit from DIBH. The primary objective of this study was to determine which patients benefit the most from DIBH by comparing percent reduction in mean cardiac dose conferred by DIBH for patients treated with whole breast RT ± boost (WBRT) versus those receiving breast/chest wall plus regional nodal irradiation, including internal mammary chain (IMC) nodes (B/CWRT + RNI) using a modified wide tangent technique. A secondary objective was to determine if DIBH was required to meet a proposed heart dose constraint of Dmean < 4 Gy in these two cohorts.MethodsTwenty consecutive patients underwent CT simulation both free breathing (FB) and DIBH. Patients were grouped into two cohorts: WBRT (n = 11) and B/CWRT + RNI (n = 9). 3D-conformal plans were developed and FB was compared to DIBH for each cohort using Wilcoxon signed-rank tests for continuous variables and McNemar’s test for discrete variables. The percent relative reduction conferred by DIBH in mean heart and LAD dose, as well as lung V20 were compared between the two cohorts using Wilcox rank-sum testing. The significance level was set at 0.05 with Bonferroni correction for multiple testing.ResultsAll patients had comparable target coverage on DIBH and FB. DIBH statistically significantly reduced mean heart and LAD dose for both cohorts. Percent reduction in mean heart and LAD dose with DIBH was significantly larger in the B/CWRT + RNI cohort compared to WBRT group (relative reduction in mean heart and LAD dose: 55.9 % and 72.1 % versus 29.2 % and 43.5 %, p < 0.02). All patients in the WBRT group and five patients (56 %) in the B/CWBRT + RNI group met heart Dmean <4 Gy with FB. All patients met this constraint with DIBH.ConclusionsAll patients receiving WBRT met Dmean Heart < 4 Gy on FB, while only slightly over half of patients receiving B/CWRT + RNI were able to meet this constraint in FB. DIBH allowed a greater reduction in mean heart and LAD dose in patients receiving B/CWRT + RNI, including IMC nodes than patients receiving WBRT. These findings suggest greatest benefit from DIBH treatment for patients receiving regional nodal irradiation.

BackgroundState-of-the-art radiotherapy of locally advanced non-small cell lung cancer (LA-NSCLC) is performed with intensity-modulation during free breathing (FB). Previous studies have found encouraging geometric reproducibility and patient compliance of deep inspiration breath hold (DIBH) radiotherapy for LA-NSCLC patients. However, dosimetric comparisons of DIBH with FB are sparse, and DIBH is not routinely used for this patient group. The objective of this simulation study was therefore to compare DIBH and FB in a prospective cohort of LA-NSCLC patients treated with intensity-modulated radiotherapy (IMRT).MethodsFor 38 LA-NSCLC patients, 4DCTs and DIBH CTs were acquired for treatment planning and during the first and third week of radiotherapy treatment. Using automated planning, one FB and one DIBH IMRT plan were generated for each patient. FB and DIBH was compared in terms of dosimetric parameters and NTCP. The treatment plans were recalculated on the repeat CTs to evaluate robustness. Correlations between ΔNTCPs and patient characteristics that could potentially predict the benefit of DIBH were explored.ResultsDIBH reduced the median Dmean to the lungs and heart by 1.4 Gy and 1.1 Gy, respectively. This translated into reductions in NTCP for radiation pneumonitis grade ≥2 from 20.3% to 18.3%, and for 2-year mortality from 51.4% to 50.3%. The organ at risk sparing with DIBH remained significant in week 1 and week 3 of treatment, and the robustness of the target coverage was similar for FB and DIBH. While the risk of radiation pneumonitis was consistently reduced with DIBH regardless of patient characteristics, the ability to reduce the risk of 2-year mortality was evident among patients with upper and left lower lobe tumors but not right lower lobe tumors.ConclusionCompared to FB, DIBH allowed for smaller target volumes and similar target coverage. DIBH reduced the lung and heart dose, as well as the risk of radiation pneumonitis and 2-year mortality, for 92% and 74% of LA-NSCLC patients, respectively. However, the advantages varied considerably between patients, and the ability to reduce the risk of 2-year mortality was dependent on tumor location. Evaluation of repeat CTs showed similar robustness of the dose distributions with each technique.

Postmastectomy radiation therapy technique and cardiopulmonary sparing: A dosimetric comparative analysis between photons and protons with free breathing versus deep inspiration breath hold

Dosimetric evaluation of lung tumor immobilization using breath hold at deep inspiration