Abstract
In the March 5 issue of Cell Stem Cell, (Murata K et al. Cell Stem Cell. 26(377–390):e376 2020) reported that intestinal stem cell recovery after injury is principally through Ascl2-dependent dedifferentiation of absorptive and secretory precursors in mice. This study provides evidence for robust regenerative capability of the intestinal epithelium via dedifferentiation of absorptive and secretory progenitors in the crypt.
Highlights
Many tissues in adults contain a population of tissuespecific stem cells, which are required for tissue homeostasis and repair (Blanpain and Fuchs, 2014; Li and Clevers, 2010)
Known as “reserve stem cell” model, the quiescent reserve stem cells, marked by Bmi1, Hopx, mTert and Lrig1, are regarded to be the regenerative cell type that can survive upon damage and repopulate Lgr5+ intestinal stem cells (ISCs)
* Correspondence: ygchen@tsinghua.edu.cn 1The State Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China Full list of author information is available at the end of the article (Barker et al, 2012)
Summary
Many tissues in adults contain a population of tissuespecific stem cells, which are required for tissue homeostasis and repair (Blanpain and Fuchs, 2014; Li and Clevers, 2010). This quick renewal process is driven by the crypt base-resident Lgr5-marked intestinal stem cells (ISCs) (Barker, 2014). The intestinal epithelium harbors an extraordinary regenerative capacity to deal with repeatedly challenges, like various injuries or inflammation, to regenerate all cell-types and restore its normal architecture even without Lgr5+ ISCs. Two models have been proposed to explain regeneration of the intestinal epithelium after damage (Barker et al, 2012).
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