Abstract
IT HAS long been known that during injections of diabetogenic anterior pituitary extracts the severity of diabetes in metahypophyseal-diabetic and depancreatized dogs is increased (1); but it is not so well established that subsequently the insulin requirements of these dogs are decreased to less than the initial levels for considerable periods of time (2). These effects are now shown to be exerted by purified growth hormone. The influences of repeated treatments with growth hormone and of variations in the insulin dosage have been studied, and the effects of deprivation of insulin and of adrenocorticotropic hormone (ACTH) have been compared to the effects produced by the growth hormone. Physiological implications of the results have already been indicated (3). methods and materials The methods used, for the analysis of blood and urine have been described previously (4). The crystalline bovine growth hormone (Campbell and Davidson, 5) was apparently homogeneous by ultracentrifugal and electrophoretic anal...
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