Abstract
BackgroundSpirometry is useful for evaluating respiratory health status and predicting health-related outcomes. As spirometry requires skilled technician and takes time, it is useful to find simple way for predicting lung function impairment. The aim of this study was to investigate which tests could predict lung function impairment among workers.MethodsThis prospective study included workers of manufacturing industry who underwent health check-ups in 2017. Subjects underwent the chronic obstructive pulmonary disease (COPD) assessment test (CAT), spirometry, and physical fitness assessments, including handgrip strength (HGS). Lung function impairment was defined as a decline in any of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), or a FEV1/FVC ratio less than the lower limit of normal (LLN).ResultsComplete data on 475 workers (366 men, 50.4% ever smokers) were available. Lung function impairment was observed in 99 subjects (64 men). Men with lung function impairment had significantly higher rate of ever-smoking, passive smoking at home in childhood, high CAT scores, and decreased HGS, compared with those without. On multivariate analyses, ever-smoking (odds ratio [OR], 2.50; 95% confidence intervals [CI], 1.25–4.97), passive smoking at home in childhood (OR, 2.71; 95% CI, 1.16–6.32), CAT scores (OR, 1.06; 95% CI, 1.01–1.12), and HGS (OR, 0.73; 95% CI, 0.57–0.92) were independently associated with lung function impairment in men.ConclusionsEver-smoking, passive smoking at home in childhood, high CAT scores, and decreased HGS are significantly associated with lung function impairment in men.Trial registrationRegistration number: UMIN000028011. Date of registration: July 1, 2017.
Highlights
Spirometry is useful for evaluating respiratory health status and predicting health-related outcomes
The study consisted of 475 subjects (366 men and 109 women) who agreed to participate in the research and underwent spirometry and physical fitness assessments
We revealed that decreased Handgrip strength (HGS) was associated with lung function impairment
Summary
Spirometry is useful for evaluating respiratory health status and predicting health-related outcomes. Spirometry is not widely applied in primary care or in health check-ups This is because the procedure is cumbersome, time-consuming, and tends to be different depending on the ability of the inspector. Some simple physical fitness assessments that can be performed in mass screenings have been reported to be associated with a wide range of health-related outcomes. The sit-to-stand (STS) test was reported to be strongly associated with mortality in COPD patients [6] We hypothesized that such simple physical fitness assessments might be predictors of lung function impairment before disease onset in healthy individuals. We investigated which factors, including questionnaires, smoking and passive smoking status, and physical fitness assessments, could predict lung function impairment among workers
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