Abstract
The salience network (SN) is composed of the insula and cingulate cortices and serves in emotional, homeostatic, sensorimotor, and cognitive functions. Being the central hub in SN, insula plays the role of interoceptive human awareness and exerts cognitive control over attentional processing, while cognitive bias happens to be a key element in the cognitive model of depression. Therefore, we first demonstrate the SN dysfunction in LLD and further test the hypothesis that SN may be the underpinning neural circuit related not only to depression severity, but also to the cognitive model of LLD.
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