Abstract
11β-Hydroxysteroid dehydrogenase (11β-HSD) activity in mesenteric arteries of 4-week- and 8-week-old Dahl rats was determined to evaluate the relationship between glucocorticoids and norepinephrine in hypertension. 11β-HSD activity (expressed as the percentage conversion of 3H-corticosterone (B) to 3H-11-dehydrocorticosterone (A)) significantly decreased in 8-week-old Dahl salt-sensitive (DS) rats (11.4 ± 1.4%) compared with Dahl salt-resistant (DR) rats (15.3 ± 0.3%) (p<0.05) when each group was fed a high-sodium chow (7%) for 4 weeks. There were no significant differences in 11β-HSD activity in the 4-week-old DS and DR rats. The enhanced response of mesenteric arteries to norepinephrine was observed only in 8-week-old DS rats. Our results suggest that a decreased 11β-HSD activity in the vascular walls contributes to the increased response of norepinephine by local increment of glucocorticoids in DS hypertensive rats.
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