iScience | VOL. 25

Deciphering the landscape of phosphorylated HLA-II ligands.

Publication Date May 20, 2022


CD4+ Tcell activation in infectious diseases and cancer is governed by the recognition of peptides presented on class II human leukocyte antigen (HLA-II) molecules. Therefore, HLA-II ligands represent promising targets for vaccine design and personalized cancer immunotherapy. Much work has been done to identify and predict unmodified peptides presented on HLA-II molecules. However, little is known about the presentation of phosphorylated HLA-II ligands. Here, we analyzed Mass Spectrometry HLA-II peptidomics data and identified 1,943 unique phosphorylated HLA-II ligands. This enabled us to precisely define phosphorylated binding motifs for more than 30 common HLA-II alleles and to explore various molecular properties of phosphorylated peptides. Our data were further used to develop the first predictor of phosphorylated peptide presentation on HLA-II molecules.

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HLA-II Molecules
Personalized Cancer Immunotherapy
Peptides Presented
Human Leukocyte Antigen Molecules
Tcell Activation
Leukocyte Antigen Molecules
Infectious Diseases
Targets For Design
Antigen Molecules
Common Alleles

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