Abstract
A gradual decrease in ribosomes and tRNA occurs during maturation of reticulocytes. The rate of decrease of ribosomes is higher than that of tRNA, so that there is a continuous increase in the proportion of tRNA to total RNA. No significant changes in the accepting activity of tRNA to a mixture of 16 amino acids could be observed during the maturation process. The decreased activity in protein synthesis of a cell-free system containing a soluble fraction of old reticulocytes could not be compensated by the addition of tRNA isolated from young reticulocytes. It is concluded that tRNA is not responsible for the diminution in the rate of protein synthesis in the maturing reticulocyte.
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