Abstract
One of the prerequisites of successful address delivery is controlling the release of encapsulated drugs. The new method of bacterial spore encapsulation in polyelectrolyte microcapsules allows for degrading the nanoscale membrane shell of microcapsules. The possibility of encapsulating spore forms of Bacillus subtilis in polystyrenesulfonate sodium/ polyallylamine hydrochloride (PSS/PAH) polyelectrolyte microcapsules was demonstrated. The activation and growth on a nutrient medium of encapsulated bacterial spores led to 60% degradation of the microcapsules nanoscale membrane shell. As a result, 18.5% of Fluorescein isothiocyanatedextran was encapsulated into polyelectrolyte microcapsules, and 28.6% of the encapsulated concentration of FITC-dextran was released into the solution.
Highlights
The main problem in the use of drugs in medicine is the lack of selectivity
The new method of bacterial spore encapsulation in polyelectrolyte microcapsules allows for degrading the nanoscale membrane shell of microcapsules
18.5% of Fluorescein isothiocyanatedextran was encapsulated into polyelectrolyte microcapsules, and 28.6% of the encapsulated concentration of FITC-dextran was released into the solution
Summary
The main problem in the use of drugs in medicine is the lack of selectivity. This can lead to many side effects, as well as a decrease in the effectiveness of drugs. The described methods involve the use of installations that generate the corresponding radiation It leads to complication of the process of destruction and its rise in price, so we propose a fundamentally new approach that allows you to destroy the shell PMC. It is proposed to use the spores of B. subtilis as an object of encapsulation and for breaking the nanoscale shell of a polyelectrolyte microcapsule This method will allow the further release of medicinal substances contained in the cavity of PMC, with the destruction of the nanoscale shell by germinating bacterial spores when injected into the nutrient medium
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