Abstract
In de voorliggende studie werd de kwaliteit van de inductie en de recovery vergeleken bij 146 paarden na totale intraveneuze anesthesie met guaifenesine, ketamine en detomidine, ten behoeve van computertomografie (CT). Ze werden willekeurig ingedeeld, waarbij de ene groep romifidine (n=110) en de andere groep detomidine (n=36) als premedicatie kreeg. De anesthesie werd geïnduceerd met een combinatie van ketamine/midazolam. De gemiddelde anesthesieduur van de CT was kort (gemiddeld +/- SD: 23,5 +/- 8,8 minuten). Er bleek geen significant verschil te zijn voor de inductiescore. Wel bleken paarden gepremediceerd met romifidine een significant betere recoveryscore te hebben.
Highlights
Alpha-2 agonists are synthetic drugs that cause sedation, analgesia and myorelaxation due to their interaction with alpha-2 adrenoreceptors that are widely distributed throughout the body
Analgesia is thought to be the result of actions on the supraspinal and spinal sites in the central nervous system, while sedation is the effect of supraspinal stimulation of alpha-2 receptors in the locus coeruleus (Williams et al, 1985)
A study by Luna et al (1996) is consistent with that of Taylor and Watkins (1992), both demonstrating that a combination of guaifenesin, ketamine and detomidine is a reliable alternative to halothane anesthesia
Summary
Alpha-2 agonists are synthetic drugs that cause sedation, analgesia and myorelaxation due to their interaction with alpha-2 adrenoreceptors that are widely distributed throughout the body. Alpha-2 agonists are generally used in veterinary practice to tranquilize animals (i.e. pharmacologic restraint). This facilitates diagnostic examinations of minimally invasive and minor surgical procedures, and limits stress experienced by the patient (Nannarone et al, 2007). A study by Luna et al (1996) is consistent with that of Taylor and Watkins (1992), both demonstrating that a combination of guaifenesin, ketamine and detomidine is a reliable alternative to halothane anesthesia. Pharmacokinetic studies performed during TIVA using the original infusion rates described by Greene et al (1986), indicated that guaifenesin concentrations increased, reaching dangerously high values after two hours of anesthesia (Taylor et al, 1995). A lower infusion rate of guaifenesin is more likely to facilitate a better recovery (Luna et al, 1996)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
