Abstract
Doublecortin (DCX) is a microtubule associated protein essential for brain development. Mutations in DCX cause severe mental disability or epilepsy due to unsuccessful neuronal migration. Previous studies have shown that DCX facilitates the formation of new microtubules and increases their lifetimes. The tertiary structure of DCX consists of two globular microtubule binding domains, an N-terminal DC domain (DC-1) and a C-terminal DC domain (DC-2). However, it remains unclear how these domains modulate microtubule dynamics.
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