Dawn of the “Bone Phenotype” in Cystic Fibrosis

Abstract

To the Editor.— We read with interest the recent article by Grey et al,1 which illustrated admirably the extent of suboptimal bone health and vitamin D and K status among a pediatric population with cystic fibrosis (CF) with relatively well preserved lung function. They appropriately suggested that the vitamin deficiencies observed may be causative and explain the low bone mass and turnover detected as reflected by the measured bone biomarkers. At our tertiary referral center, we previously examined similar relationships between fat-soluble vitamin deficiencies, bone fragility, and pulmonary function in …