Abstract
<div>Abstract<p>Large intergenic noncoding RNAs (lincRNA) have been less studied than miRNAs in cancer, although both offer considerable theranostic potential. In this study, we identified frequent upregulation of miR-196a and lincRNA <i>HOTAIR</i> in high-risk gastrointestinal stromal tumors (GIST). Overexpression of miR-196a was associated with high-risk grade, metastasis and poor survival among GIST specimens. miR-196a genes are located within the <i>HOX</i> gene clusters and microarray expression analysis revealed that the <i>HOXC</i> and <i>HOTAIR</i> gene were also coordinately upregulated in GISTs which overexpress miR-196a. In like manner, overexpression of <i>HOTAIR</i> was also strongly associated with high-risk grade and metastasis among GIST specimens. RNA interference–mediated knockdown of <i>HOTAIR</i> altered the expression of reported <i>HOTAIR</i> target genes and suppressed GIST cell invasiveness. These findings reveal concurrent overexpression of <i>HOX</i> genes with noncoding RNAs in human cancer in this setting, revealing miR-196a and <i>HOTAIR</i> as potentially useful biomarkers and therapeutic targets in malignant GISTs. <i>Cancer Res; 72(5); 1126–36. ©2012 AACR</i>.</p></div>
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
