Abstract
<div>Abstract<p><b>Background:</b> Epidemiologic evidence on the association between nut consumption and lung cancer risk is limited.</p><p><b>Methods:</b> We investigated this relationship in the Environment and Genetics in Lung Cancer Etiology (EAGLE) study, a population-based case–control study, and the National Institutes of Health (NIH) American Association of Retired Persons (AARP) Diet and Health Study, a prospective cohort. We identified 2,098 lung cases for EAGLE and 18,533 incident cases in AARP. Diet was assessed by food frequency questionnaire for both studies. Multivariable ORs and HRs and respective 95% confidence intervals (CI) were calculated using unconditional logistic regression and Cox proportional hazards regression for EAGLE and AARP, respectively.</p><p><b>Results:</b> Higher frequency of intake of nut consumption was inversely associated with overall lung cancer risk (highest vs. lowest quintile, OR<sub>EAGLE</sub> = 0.74; 95% CI, 0.57–0.95; HR<sub>AARP</sub> = 0.86; 95% CI, 0.81–0.91), regardless of smoking status. Results from the prospective cohort showed similar associations across histologic subtypes and a more pronounced benefits from nut consumption for those who smoked 1 to 20 cigarettes/day (OR<sub>EAGLE</sub> = 0.61; 95% CI, 0.39–0.95; HR<sub>AARP</sub> = 0.83; 95% CI, 0.74–0.94).</p><p><b>Conclusions:</b> Nut consumption was inversely associated with lung cancer in two large population-based studies, and associations were independent of cigarette smoking and other known risk factors.</p><p><b>Impact:</b> To our knowledge, this is the first study that examined the association between nut consumption and lung cancer risk by histologic subtypes and smoking intensity. <i>Cancer Epidemiol Biomarkers Prev; 26(6); 826–36. ©2017 AACR</i>.</p></div>
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.