Abstract

<div>Abstract<p><b>Purpose:</b> To evaluate the prognostic utility of immunohistochemical assessment of key proteins in multiple DNA repair pathways in triple-negative breast cancer (TNBC; estrogen receptor negative, progesterone receptor negative, and HER2/neu negative by immunohistochemistry).</p><p><b>Experimental Design:</b> Archived clinically annotated tumor specimens from 112 women with TNBC were immunostained with antibodies against DNA repair proteins and scored using digital image analysis. The cohort was divided into training and test sets for development of a multiantibody model. Scores were combined with clinical data to assess association with outcome.</p><p><b>Results:</b> Low XPF (<i>P</i> = 0.005), pMK2 (<i>P</i> = 0.01), MLH; <i>P</i> = 0.002), and FANCD2 (<i>P</i> = 0.001) were each associated with shorter time to recurrence (TTR) in univariate analysis. A 4-antibody model could segregate high-risk and low-risk groups on the basis of TTR in both the training (relative risk [RR] = 3.52; <i>P</i> = 9.05E-07) and test (RR 2.67; <i>P</i> = 0.019) cohorts.</p><p><b>Conclusions:</b> DNA repair proteins may be useful as prognostic markers in TNBC. Further study in larger, uniformly treated cohorts with additional clinical parameters is warranted. <i>Clin Cancer Res; 16(23); 5796–804. ©2010 AACR.</i></p></div>

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.