Abstract
Dapsone (4,4'-Diaminodiphenylsulphone) is simplest, oldest, cheapest, most active antibacterial agent belongs to sulphone family. It is used to treat various infections such as Hansen?s disease, cutaneous mycetoma, Pnemocystis carinii etc. It is also employed in many immune and hypersensitivity disorders like dermatitis herpetiformis, vasculitis, polyartritis nodosa etc. Dapsone can cause several adverse reactions ranging from simple rashes to multiorgan involvement. Here we are reporting a rare case so called dapsone syndrome or DHS (Dapsone Hypersensitivity Syndrome), which include skin eruption (rash), fever and internal organ involvement like hepatobiliary, pulmonary, hematological and neurological and others. Our patient presented with fever, skin eruption, jaundice, and anaemia which responded to withdrawn of dapsone and intravenous steroids.
Highlights
Dapsone (4,4,diaminodiphenylsuphone) compound is related to sulphone drug group family first synthesized by Fromm and Wittmann in 1908
Dapsone is used as a first line drug for leprosy since long time, and been used for other dermatological condition like dermatitis herpetiformis and infection such as Pnemocystis carinii in patient with AIDS
In 1950, Lowe reported the first case of Dapsone Hypersensity, later on Allday and barnes coined the term DHS (Dapsone Hypersensitivity Syndrome)
Summary
Dapsone (4,4,-diaminodiphenylsuphone) compound is related to sulphone drug group family first synthesized by Fromm and Wittmann in 1908. On third day we found that patient was not responding to treatment and fever didn’t subside and on serial investigation we found that his total bilirubin was raised to 12.4 mg/dl (direct-8.2 mg/dl) and AST/ALT was 900/906, PT was 17.9 secs (INR 1.57) and TLC was still higher 18200/mm. On third day we found that patient was not responding to treatment and fever didn’t subside and on serial investigation we found that his total bilirubin was raised to 12.4 mg/dl (direct-8.2 mg/dl) and AST/ALT was 900/906, PT was 17.9 secs (INR 1.57) and TLC was still higher 18200/mm3 After all these findings and unresponsiveness to empirical treatment, we suspected this to be a. After 2 weeks patients came to us with normal biochemical investigations
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