Abstract
We found that chronic d-penicillamine administration in guinea pigs may induce a variety of electrophysiologic, histologic, and serologic changes that are reminiscent of features of both experimental allergic myositis and experimental allergic myasthenia gravis. These include (i) electromyographic decrement following repetitive stimulation that is reversible with edrophonium, and augmentation of twitch tension with edrophonium; (ii) nonspecific inflammatory and necrotic changes in muscle; and (iii) significant elevation of acetylcholine receptor antibody. The guinea-pig model raises several questions that must be answered before it can be regarded as a reliable model of d-penicillamine-induced neuromuscular disease in humans.
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