Abstract
The open channel blocking action of the Ca 2+ antagonists, D-600 and Cd 2+, was investigated in single neurons isolated by enzymatic treatment from dorsal root ganglia of frog. Using a ‘concentration clamp’ (jump) technique Ca 2+ antagonists were applied to the preparation just before (less than 100 ms) or during a depolarizing step which induced the maximal peak amplitude of Ca 2+ current ( I Ca). The inhibitory action of D-600 was more pronounced when applied during a depolarizing step than when applied just before a depolarizing step. In contrast, Cd 2+ was equally inhibitory, whether applied before or during the depolarization. Thus, D-600 affects open channels more quickly or more profoundly than closed ones, while Cd 2+ acts equally on both open and closed Ca 2+ channels.
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