Abstract

In this approach, Hepatocellular carcinoma (HCC) is originated from hepatocytes cell, which can spread several parts in the body. It increases the death rate of cancer patients and more common in men rather than female. Patients having large tumor are growing through expensive treatment such as chemotherapy, radiotherapy and surgery. Nano medicine such as nano-dimensional particles as well as quantum dots might be an alternative treatment with greater efficiency in cancer biology field. Modification of surface and chemical properties of cadmium groups quantum dots can easily penetrate into the cancer cell without harming normal tissues. Here, Cadmium-Selenium Quantum Dot nanomaterials (CdSe QDs) have been prepared in solution phase with 0.1 M concentration, which was potentially applied for the destroying of HepG2 cancer cell with 24 hour and 36 hour of incubation. Due to their size, surface properties, lower cost, QDs can easily attached to the cell and able to damage the cells more rapidly in vitro process. For cell death, gene expression and morphological changing analysis were completed MTT, Flow Cytometry, qRT-PCR assay. Finally, the cell deaths were observed by cell shrinkage, rupture of membrane and expression of apoptotic gene (Bcl2, Beta catenin, Bax) were positive comparing untreated HepG2 cell line.

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.