Abstract
The aim of this study is to determine the cytotoxicity of three different nano composite resins (CRs) on human gingival fibroblast (hGF) and periodontal ligament fibroblast (hPDLF) cell lines. These CRs selected were nanohybrid organic monomer-based Admira Fusion (AF), nanohybrid Bis-(acryloyloxymethyl) tricyclo [5.2.1.0.sup.2,6] decane-based Charisma Topaz (CT), and supra nano filled resin-based Estelite Quick Sigma (EQS). MTT assay was performed to assess the cytotoxicity of CRs at 24 h and one week. AF and EQS applied on hGF cells at 24 h and one week demonstrated similar cytotoxic outcomes. Cytotoxicity of CT on hGF cells at one week was higher than 24 h (p = 0.04). Cytotoxicity of CT on hGF cells was higher at 24 h (p = 0.002) and one week (p = 0.009) compared to control. All composites showed higher cytotoxicity on hPDLF cells at one week than the 24 h (AF; p = 0.02, CT; p = 0.02, EQS; p = 0.04). AF and EQS demonstrated lower cytotoxicity on hPDLF cells than the control group at 24 h (AF; p = 0.01, EQS; p = 0.001). CT was found more cytotoxic on hPDLF cells than the control (p = 0.01) and EQS group (p = 0.008) at one week. The cytotoxicity of CRs on hGF and hPDLF cells vary, according to the type of composites, cell types, and exposure time.
Highlights
Dental restorations are widely used to repair the function and aesthetics by ensuring tooth surface integrity
Under the light of these findings, the aim of this study is to evaluate the in vitro cytotoxicity effect of three different monomer-based nano Composite resins (CRs) on human gingival fibroblast (hGF) and human periodontal ligament fibroblast cell lines for 24 h and one week time periods
Admira Fusion (AF) and Estelite Quick Sigma (EQS) CRs displayed no cytotoxic effect on the hGF cells at 24 h compared to the control group (p > 0.05) (Table 1)
Summary
Dental restorations are widely used to repair the function and aesthetics by ensuring tooth surface integrity. Composite resins (CRs) are still the most common used dental restorative material in dental practice and revolutionized restorative dentistry in the mid-20th century. In addition to their aesthetic success, some of the advantages include stability in the oral environment and ease of application. Resin-based composites possess disadvantages such as polymerization shrinkage, the risk of secondary caries due to unsuccessful connection between resin and dentin, high thermal expansion coefficient and low wear resistance compared to metal-based restorations. To overcome these disadvantages, the structure of the CRs
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