Abstract
This study was conducted to evaluate the anticancer effect of Eriobotrya japonica (loquat) fruit juice on cancer cell lines (in vitro) and its antioxidant activity. Study was performed on two cancer cell lines, human cervical cancer (Hela), rhabdomyo sarcoma (RD), and rat embryogenic fibroblast (REF) as a normal cell, at concentrations of 62.5, 125, 250, 500 and 1000 µg/ml of fruit juice were measured at 24, 48, and 72-hr. with three replicates. Free radical 1,1Dyphenyl-2-picrylhydrazyl radical (DPPH) was used for testing the ability as antioxidant on 25, 50, 75, 100, 150 µg/ml concentration of the loquat fruit juice. The results revealed that the juice of E. japonica had high antioxidant influence (100%) in 150 µg/ml concentration, followed by 88% in 100 µg/ml concentration. Effect of growth inhibition of cancer cells was depended on juice concentration. The effect of juice on Hela cell line was more than on RD, while the highest effect of juice on Hela was shown on concentration of 500 µg/ml the 48 hr. The cytotoxic effect of exhibited that had a significant effect (P<0.05).
Highlights
كمضاد عمى الخطوط السرطانيةEriobotrya Japonica صممت ىذه الد ارسة لتقدير تأثيرعصير ثمار نبات الينكي دنيا
Cytotoxic Activity The cytotoxic activity was determined by higher antioxidant influence by 100% in 150 μg/ml concentration than 88% in 100 μg/ml concentration as compared with the standard using five different concentrations of juice of E. japonica plant on two cancer cell lines and one normal cell line after 24, 48 and 72 hours control Ascorbic acid.The results showed that there was significant difference (P≤0.05) between the concentrations in the same juice exposure time
The statistical analysis indicated that the concentrations of the fruit juice have a extract.The results of this study indicate that juice plant have the ability to scavenge free radicals when compared with reference significant cytotoxic effect on HeLa and rhabdomyo sarcoma (RD) after 24, 48 and 72 hours at levels (P
Summary
Results obtained from the general chemical detection showed the presence of phenols, Where A518 control is the absorbance of DPPH tannins, terpenoids, and flavonoids, in juice radical + methanol; A518 sample is the extract. These experimental repeated triplicate for Juice extract of E. japonica plant was used as fruit extract
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