Abstract
The aim of this six-centre, split-sample study was to compare ThinPrep® fluid-based cytology to the conventional Papanicolaou smear. Six Cytopathology laboratories and 35 Gynaecologists participated. 5428 patients met the inclusion criteria. Each cervical sample was used first to prepare a conventional Pap smear, then the sampling device was rinsed into a PreservCyt® vial, and a ThinPrep slide was made. Screening of slide pairs was blinded. On initial screening, 29 % more ASCUS and 39 % more low-grade squamous intraepithelial lesions (LSIL) and more severe lesions (LSIL+ ) were detected on the ThinPrep slides than on the conventional smears (p=0.001). Independent and consensus review confirmed 145 LSIL+ diagnoses ; of these, 18 % more had been detected initially on the ThinPrep slides than on the conventional smears (p= 0.041). The ThinPrep Pap Test is more accurate than the conventional Pap Test and has the potential to optimize the effectiveness of primary cervical cancer screening.
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