Abstract
Gastrointestinal stromal tumor (GIST), which is associated with mutations in KIT or a platelet-derived growth factor receptor, alpha polypeptide (PDGFRA), is the most common mesenchymal tumor of the gastrointestinal tract[1]. A definitive diagnosis of GIST is important to ensure administration of effective drugs, such as imatinib mesylate, and immmunohistochemical staining for c-Kit or DOG1 is useful for the diagnosis. According to previous studies, cytokeratin (CK) expression is a rare event in GISTs[2-6], so they can easily be misdiagnosed as other epithelial or epithelioid mesenchymal tumors. In such cases, a diagnosis of GIST can be made when DOG1 immunoreactivity or mutation of KIT or PDGFRA are observed.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
