Abstract
Systemic administration of corticosteroids r is an important risk factor for the development of various forms of candidiasis [i, 5, 7, 8] which is linked with the general immunodepressive effect of these hormones. Meanwhile local application of CS to the mucous membranes in small doses which do not change the blood hormone levels and have no immunodepressive effect can also lead to the development of candidiasis. In particular, in the treatment of bronchial asthma with aerosols containing CS, the development of candidiasis of the mucosa of the mouth, pharynx, and larynx has been observed with a frequency proportional to the duration of administration of CS and their dose [2, 6, 9]. The writers have reproduced experimentally the development of candidasis of the oral mucosa following local application of CS and have studied some of its cytohistological mechanisms.
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