Abstract
Aim. The main goal of this study was to study the anti-radiation effect of guaninium-zinc chloride complex on cytogenetic changes in irradiated rats. Methods. White rats of the Wistar line with an average weight of 110-125 grams served as the material for the detection of the anti-radiation effect of guaninium-zinc chloride complex. Animals were injected intraperitoneally with solutions of guaninium-zinc chloride complex at a concentration of 40 mg/kg 2 hours before irradiation and were subjected to general uniform gamma irradiation from a 60Co source in the Rukhund-20000 irradiation unit at a dose of 3 and 5 Gy. Results. Cytogenetic analysis of animals showed that with a single injection of guaninium-zinc chloride complex solutions before irradiation, the proportion of chromosomal abnormalities decreased markedly, and reached 2.93 %, and the amount of abnormal spermatozoa markedly decreased. Guaninium-zinc chloride complex softened the damaging effects of ionizing radiation. There was no suppression of cell division. Conclusions. It was found for the first time that, with the introduction of a solution of guaninium-zinc chloride complex in white Wistar rats before irradiation, it reduces the damaging effect of gamma irradiation. The obtained data gives grounds to assume that the guaninium-zinc chloride complex tested by us can be recommended as a promising anti-radiation agent.
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