Abstract
Editorials1 December 1983Cyclosporine NephrotoxicityWILLIAM M. BENNETT, M.D., JOSEPH P. PULLIAM, M.D.WILLIAM M. BENNETT, M.D.Search for more papers by this author, JOSEPH P. PULLIAM, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-99-6-851 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCyclosporine is a potent new immunosuppressive agent that selectively inhibits T-cell function, allowing survival of allografts without myelosuppression. Its use should minimize the many adverse effects of long-term steroid therapy. Although the long-term effects of cyclosporine on renal allograft longevity are not well documented, enthusiastic reports in the medical literature and lay press have led to an unprecedented anticipation by prospective allograft recipients, particularly patients with chronic renal failure receiving long-term dialysis. However, these reports have not sufficiently emphasized the nephrotoxicity that frequently accompanies cyclosporine therapy.Cyclosporine is a lipophilic molecule with a molecular weight of 1202 daltons. When the...
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