Abstract
Pretreatment of rat renal mesangial cells with the immunosuppressive drug cyclosporin A caused a dose-dependent increase in the angiotensin II, [Arg 8]vasopressin and noradrenalin-stimulated rise in intracellular free calcium as measured with quin 2. Cyclosporin A had no significant effect on basal cytosolic free calcium. However, cyclosporin A increased the basal 45Ca 2+ influx. This stimulated 45Ca 2+ influx was not blocked by nifedipine (10 −6 M). Cyclosporin A also augmented the angiotensin II, [Arg 8]vasopressin and noradrenalin-stimulated efflux of 45Ca 2+ from mesangial cells. These results suggest that cyclosporin A stimulates transmembrane Ca 2+ influx in mesangial cells and also augments the vasoconstrictor-induced increases in cytosolic free calcium.
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