Abstract
Cyclin D1 expression was positive in 35 cases of oral cancer with a Cyclin D1 positivity of 22.16?22.18. The percentage of positive cases as well as Cyclin D1 positivity showed an increase as the grade of differentiation advanced. No significant association was found between Cyclin D1 positivity and degree of differentiation of tumors (p=0.138). A significant difference in Cyclin D1 positivity was observed (p=0.043) comparing well differentiated (16.61?17.89) and poorly differentiated (37.0?32.51) tumors, as well as between well differentiated (16.61?17.89) and moderately differentiate tumors (24.38?21.93; p=0.002). Similarly, significant difference in Cyclin D1 positivity was observed comparing moderately differentiated (24.38?21.93) and poorly differentiated tumors (37.0?32.51; p=0.043). Cyclin D1 expression was more frequently seen in hard palate (75%), buccal mucosa (67%) and lip (60%) while expression of Cyclin D1 was less frequent in sites like gingiva (0%), tongue (40%) and floor of mouth (43%). There was no association between Cyclin D1 expression and primary site of oral cancer (p=0.528) in tobacco and betel quid chewers of northern India.
Highlights
SUMMARYArch Oncol 2018; 24(1): Cyclin D1 expression was positive in 35 cases of oral cancer with a Cyclin D1 positivity of 22.16±22.18
No significant association was found between Cyclin D1 positivity and degree of differentiation of tumors (p=0.138)
Cyclin D1 Expression Tissues of Oral Squamous Cell Carcinoma (OSCC) patients with tobacco and betel quid chewing habit (60 specimens) and 10 normal oral tissues were subjected to immunohistochemical staining for expression of Cyclin D1 using H-295 antibody (Santa Cruz Biotechnology, USA)
Summary
Arch Oncol 2018; 24(1): Cyclin D1 expression was positive in 35 cases of oral cancer with a Cyclin D1 positivity of 22.16±22.18. Oral Squamous Cell Carcinoma (OSCC) arise as a consequence of multiple molecular events induced by the effects of various carcinogens from habits such as areca nut and betel quid chewing, influenced by environmental factors, possibly viruses in some instances, against a background of inheritable resistance or susceptibility [4]. Several alterations in the expression of tumor suppressor genes and oncogenes in the development of OSCC have been described [6,7,8] Based on these facts, the present study was done to investigate the expression of Cyclin D1 and to further examine the relationship between Cyclin D1 expression with different histological grades in oral squamous cell carcinoma (OSSC) patients from north India possessing tobacco and betel quid chewing habits. A probability (p value) of less than 0.05 was accepted as statistically significant
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