Abstract
The application of dibutyryl cyclic adenosine monophosphate (d-cAMP) to an isolated, voltage clamped node of Ranvier resulted in an increase in the peak inward and steady-state outward current amplitudes. Blocking K + channels with TEA abolished the effects of d-cAMP on Na + currents. Blocking Na + channels with TTX revealed an increase in K + current amplitude in response to d-cAMP. Application of a potent phosphodiesterase inhibitor, SQ20009, reproduced the effects of d-cAMP in the intact node, but with a latency in onset. These results suggest a physiological role for cAMP in the modulation of Na + and K + currents in myelinated peripheral nerve.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
