Abstract
Objective. The study aimed to explore the influence of dexmedetomidine (Dex) guided by ultrasonic contrast on postoperative cognitive function, serum nerve injury factors, inflammatory response, and blood glucose in patients undergoing intracerebral tumor resection through curve fitting algorithm. Methods. 80 patients who underwent tumor resection were selected and randomly rolled into control (Ctrl) group and Dex group, with 40 in each. Then, patients in the Dex group received 0.4 μg/kg⋅h Dex, and patients in Ctrl received the same amount of normal saline. Both groups were diagnosed with benign or malignant tumors by contrast-enhanced ultrasound (CEUS) based on time-intensity curve (TIC) before surgery. Cognitive Capacity Screening Examination (CCSE) and Montreal Cognitive Assessment (MoCA) were used to assess the cognitive function 1 day before and 3 days after the operation, and the ELISA method was used to detect levels of nerve damage-related factors and inflammation factor. Finally, the fasting blood glucose (FBG) levels were detected at the same time. Results. In contrast with benign lesions, the AUC, MTT, and PI of malignant lesions were obviously reduced ( P < 0.05 ), while TP was obviously increased ( P < 0.05 ). The postoperative CCSE and MoCA scores of the Dex group were obviously higher than Ctrl ( P < 0.05 ). In contrast with the Ctrl, the CCSE and MoCA scores in the Dex group increased obviously after 3 days ( P < 0.05 ). In addition, the incidence of postoperative cognitive dysfunction (POCD) in the Dex group was obviously reduced ( P < 0.05 ). Besides, levels of S100β, NSE, and GFAP were obviously reduced in the Dex group 1 day after surgery ( P < 0.05 ), while levels of IL-6 and TNF-α were obviously reduced ( P < 0.05 ), and returned to the level of Ctrl 3 days after surgery. There was no obvious difference in FBG at each time point between the two. Conclusion. CEUS based on curve fitting algorithm is effective on nursing treatment of intracranial tumors. Dex can obviously improve POCD and reduce levels of serum nerve injury factors and inflammatory factors.
Highlights
Brain tumor is a relatively common neurological disease in clinical practice
Eighty patients who underwent tumor resection in hospital from January 2019 to January 2020 were selected as research subjects, including 44 males and 36 females. ey were between 53 and 65 years old, with an average age of (57.85 ± 6.94) years. e control group (Ctrl) had 40 patients, including 19 males and 21 females, aged 50–61 years, with a mean age of (60.16 ± 7.2) years; the Dex group had 40 patients, including 25 males and 15 females, aged 55–65 years, with a mean age of (61.09 ± 6.9) years. is study had been approved by the Ethics Committee of hospital, and all the study objects and their families were informed and voluntarily agree to participate in this study
contrast-enhanced ultrasound (CEUS) based on curve fitting algorithm is effective on the diagnosis of intracranial tumors
Summary
Brain tumor is a relatively common neurological disease in clinical practice. Because the compression of tumor will cause increased intracranial pressure, there will be invasive operation during surgery causing hemodynamic changes and brain tissue hypoxia and ischemia, which will lead to irreversible damage to the neurological function and cognitive function [1, 2]. Postoperative cognitive dysfunction (POCD) is a possible postoperative complication in patients undergoing general anesthesia surgery, causing memory loss, reduced living ability, psychological abnormalities, and decreased orientation in patients [3]. Dexmedetomidine (Dex) is an anesthetic widely used in clinical practice, which has analgesic and sedative effects, has little effect on hemodynamics, and can reduce the damage of surgery and anesthetic drugs to brain tissue to a certain extent and play a role in cerebral protection [6, 7]. It is well known that Dex has the similar nursing effect of opioids, and these characteristics make it a Scientific Programming suitable choice for sedatives in intensive care unit (ICU) and perioperative conditions [8]
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