Abstract
Ordered assembly of cellular processes in the form of oscillations and waves is an emerging theme in living cells. Occurrences of such patterns indicate the presence of local and global coupling mechanisms. However, the nature of the coupling remains to be determined. In our recent work, we discovered a striking appearance of FBP17, one of the Bin1/amphiphysin/Rvs167 (BAR) domain proteins, in actin waves of stimulated mast cells. In addition to being a reporter, FBP17 is essential for wave formation. BAR domain proteins are widely known for their curvature sensing and inducing capabilities, motivating us to directly visualize membrane shape and test its function. We will discuss our findings on the role of physical parameters such as membrane curvature and plasma membrane tension in the propagation of waves. Collectively, our work suggests a mechanochemical basis for pattern formation, which regulates the dynamic reorganization of cell cortex in response to external stimulation, the first and essential step of cellular activation.
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