Abstract
Periodontitis can be defined as a multifactorial inflammatory disease of bacterial origin causing destruction of periodontal tissues. Achieving effective regeneration in periodontal therapy still remains a foremost goal. Chemical modification of tooth surface has been the most persistent effort to achieve periodontal regeneration. There are controversies regarding effectiveness of root biomodification due to a mixture of results from clinical and histological studies. This review provides an acumen about root biomodification in clinical conditions as well as a summary on the novel biomodification agents.
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