Current status of prevalence and risk factors associated with liver fluke Fasciola hepatica in cattle raised in different altitudinal regions of Colombia.

Abstract

Fasciola hepatica is a trematode parasite with a worldwide distribution that affects mammals, including humans, and is considered a major food safety and public health problem. A research was conducted in three hundred eighty-five livestock farms located in different altitudinal regions of Colombia between February 2017 and March 2018 with the aim to determine the coprological prevalence, seroprevalence (SP) and risk factors associated with liver fluke F. hepatica. A total of 5620 fecal sample were collected from cattle and processed using sedimentation technique. Additionally, 597 blood samples were collected and processed by an ELISA test. The coprological prevalence of F. hepatica in animals and herds was 6.4% and 38.4%, respectively. Regarding the prevalence by municipalities, there was statistical association (P<.05), indicating that the prevalence was higher in those municipalities above 2000 masl (meters above sea level). Regarding risk factors, cattle raised in municipalities at 2000 to 3000 masl showed about 4 (OR=3.96 [CI95% 3.1-5]; P<.05) times higher probability for infection than those raised at lower altitude. Cattle from 2 to 3year of age, showed almost 4 times (OR=3.7[CI95% 2.5-5.4]; P<.05), increased infection risk. Females and dairy breeds showed almost 2 (OR=1.9 [CI95% 1.3-2.6]; P<.05) and 10 times (OR=10 [CI95% 7.8-12.8]; P<.05), respectively, increased infection risk. The presence of antibodies anti- F. hepatica (SP=37.8%; [CI95% 35.8-39.7]; P<.05) in cattle of the region under study is confirmed, which suggests an endemic behavior of this parasitosis. The present study provides current information on the prevalence of F. hepatica in different altitudinal regions of Colombia, and these findings could be useful for designing new holistic control measures for the liver fluke F. hepatica infection.